Syrup Presentation

Each 5 ml contains:
Sodium Picosulfate 5 mg

Sodium picosulfate is a laxative and is used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery

Uses

• Bowel preparation therapy
• To clean GIT
• Constipation

Mechanism of action

Sodium picosulfate is a stimulant laxative that in conjunction with magnesium citrate, produces a purgative effect on stools. Sodium picosulfate inhibits the absorption of water and electrolytes, and increases their secretion into the intestinal lumen. It is hydrolyzed by colonic bacterial enzyme, sulfatase, to form an active metabolite bis-(p-hydroxy-phenyl)-pyridyl-2-methane (BHPM), which acts directly on the colonic mucosa to stimulate colonic peristalsis.

Side Effects

The product is possible safe for most adults. There is no disadvantage associated with the product if taken under the recommended usage however severe electrolyte disturbances, dehydration, hypovolemia and nausea can occur in some patients.

Interactions

Digoxin, iron, tetracycline antibiotics, quinolone antibiotics such as ciprofloxacin/levofloxacin, chlorpromazine, penicillamine can interact with sodium picosulfate.

Contraindication

The formulation should not be used in the following conditions:

• Ileus
• Gastrointestinal obstruction, ulceration or perforation
• Acute abdominal surgical conditions including appendicitis
• Acute inflammatory bowel diseases